56 percent of Americans believe NAFTA has benefited the United States. Only among Republican voters do a majority believe the contrary.
Trump has denounced NAFTA as a "disaster" and the worst agreement ever signed by the United States, blaming it for a $64 billion trade gap with Mexico and loss of countless jobs.
According to Monica De Bolle, senior fellow at the Peterson Institute for International Economics, different trade bodies and organizations are working to convince the Trump administration "to move away from his very hard rhetoric."
Exiting NAFTA would be a grave mistake that could, among many other painful outcomes, devastate American agriculture, including wheat producers, according to the chamber.
Beth Ann Bovino, chief US economist at S&P Global Ratings, said many people were unaware of how trade had grown since NAFTA took effect in 1994.
"It has tripled since NAFTA was initiated," she told AFP.
She said the agreement had strengthened competitiveness among manufacturers by forcing businesses to innovate, "which has increased employment and investment opportunity in the end."
Exiting the treaty would drive up prices, slowing consumer spending -- a mainstay of the US economy -- and depressing corporate revenues as a result, Bovino added.
Citing an ImpactECON study, she said job losses for unskilled workers could rise as high as 250,000 positions in the three to five years following a withdrawal.
Adding skilled labor would see job losses rise by another million positions.