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Good luck on your mission Theresa May.
Here's what's in store for the UK.
I'm delighted to be a European 'tis all I can say.
US lobby groups for agriculture and pharmaceutical firms want UK standards changed to be closer to those of the US in a post-Brexit trade deal.
The meat lobby wants the sale of growth hormone-fed beef, currently banned in the UK and EU, to be allowed in the UK.
The drugs company lobby wants changes to the NHS drugs approval process to allow it to buy more of US drugs.
The farming groups say any deal should move away from EU standards, including rules governing genetically modified crops, antibiotics in meats, and pesticides and herbicides, such as glyphosate.
US companies - especially in the agricultural sector - said they hoped the UK would prove more flexible than the EU.
The groups said a new deal could create a trans-Atlantic market "that can act as a bastion against the EU's precautionary advances and its ongoing aggressive attempts to spread its influence around the globe".
The groups, which as well as meat, drug and technology firms include producers of olive oil, wine, nuts, fruit, and dairy products, say they want to see the UK reduce tariffs on food products. They also want to limit geographic labelling rules, such as those that bar US companies from using terms such as Prosecco.
The Animal Health Institute, which produces animal antibiotics, was among several groups that said it would not support a deal that did not address demands by the US agricultural sector.
PhRMA, which represents drug makers in the US such as AbbVie Merck and Novartis, said it wanted a deal to address the barriers to access it currently faces in the UK, pointing to items such as government price controls.
The organisation, as well as some other groups, are also hoping to secure patent protections for certain types of drugs for at least 12 years, among other demands.
Technology groups are also setting out their wishlists for any pact. Companies in this sector are against the UK's proposed digital tax.
The UK government has promised to look at ways of taxing US technology giants, such as Amazon and Google, which critics say do not pay their fair share of tax in the UK and therefore operate at an unfair advantage to physical companies.